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氯吡格雷抵抗的研究现状 被引量:6

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摘要 氯吡格雷是一种新型的噻吩啶类衍生物,能够抑制血小板的活化和聚集,其与血小板表面二磷酸腺苷(ADP)受体P2Y12不可逆结合,可减少ADP的结合位点,阻断ADP对腺苷环化酶的抑制作用,促进环单磷酸腺苷(cAMP)依赖和前列腺素E1(PGE1)刺激的舒血管物质磷酸蛋白(VASP)的磷酸化,
作者 黄瑛
出处 《中国循证心血管医学杂志》 2011年第4期311-312,共2页 Chinese Journal of Evidence-Based Cardiovascular Medicine
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