摘要
目的:探讨影响米非司酮配伍米索前列醇药物终止早孕结局的相关因素,为选择合适的终止早孕方法提供思路。方法:以药物流产后因不全流产或失败行手术干预者为病例组,以药物流产后完全流产者为对照组,采用病例-对照研究的方法,按1:4比例匹配对照组,分析药物流产时手术干预的相关影响因素。结果:经单因素分析,药物流产后需手术干预的相关影响因素为孕次(OR=2.051,P<0.001)、流产次数(OR=2.677,P<0.001)、有分娩史(OR=2.328,P<0.001)、孕囊直径(OR=2.115,P<0.001)、子宫前倾前屈位和后倾后屈位(OR=2.031,P<0.001;OR=2.384,P<0.001)。经多因素分析,药物流产后需手术干预的危险因素为孕次(OR=2.317,P<0.001)、流产次数(OR=1.897,P<0.001)、孕囊直径(OR=1.196,P<0.001)和子宫位置(OR=1.494,P>0.05)。结论:妊娠次数多(≥3次)、流产次数多(≥3次)、孕囊直径大(>25mm)、屈位子宫(前倾前屈或后倾后屈)的早孕妇女选择药物流产时需要手术干预的可能性较大,而剖宫产史与药物流产结局无明显相关性。
Objective： To explore influencing factors of the outcome of early medical abortion using mifepristone combined with misoprostol. Methods：Women were recruited and divided into two groups according to the outcome of early medical abortion （ successful abortion or failure abortion requiring an additional surgical treatment）. The influencing factors were evaluated. Results： The univariate analysis results showed that factors included the number of pregnancy （ OR = 2. 051, P 〈 0. 001 ） and abortion （ OR = 2. 677, P 〈 0. 001 ）, a history of delivery （ OR = 2. 328, P 〈 0.001 ）, the diameter of gestational sac （ OR = 2. 115, P 〈0. 001 ） and the position of uterus （anteversion and antexion or retroversion and retroxion, （OR = 2. 031 and 2. 384, P 〈0.001 ）. The multivariate analysis results showed that risk factors included the number of pregnancy （OR = 2. 317, P 〈 0.001 ） and abortion （ OR = 1. 897, P 〈 0.001 ）, the diameter of gestational sac （ OR = 1. 196, P 〈 0.001 ） and the position of uterus （ OR = 1. 494, P 〉 0.05 ）. Conclusion ： Women with more than three times of pregnancy as well as abortion and more than 25 mm of gestational sac diameter could be at a great risk for abortion failure. Woman with an anteversion and antexion uterus or a retroversion and retroxion uterus tends to be failure in termination of early pregnancy using mifepristone combined with misoprostol. While a history of caesarean section has no relation with the outcome of medical abortion.
出处
《中国计划生育学杂志》
北大核心
2011年第11期680-683,共4页
Chinese Journal of Family Planning
关键词
米非司酮
药物流产
手术流产
影响因素
Mifepristone
Medical abortion
Surgical abortion
Influencing factor
