摘要
目的观察丹参酮ⅡA治疗川崎病(KD)的临床效果。方法将61例住院KD患儿随机分为对照组和治疗组,其中对照组32例,给予常规治疗(静脉丙种球蛋白+阿司匹林);治疗组29例,在对照组治疗的基础上加用丹参酮ⅡA治疗5～7 d。观察治疗过程中患儿的临床症状、体征、超声心动图、CRP、ESR、心肌同工酶变化情况。结果治疗组患儿用药后热退时间为(16.27±3.42)h,对照组患儿为(22.78±7.53)h,2组比较差异有统计学意义(P<0.05);用药后治疗组CRP降至(9.72±2.82)mg.L-1,对照组患儿CRP降至(14.68±2.90)mg.L-1,2组比较差异有统计学意义(P<0.05);治疗组、对照组在疾病初诊时冠状动脉扩张率分别为20.69%、21.88%,2组比较差异无统计学意义(P>0.05),病程2～3周、1个月、2个月治疗组冠状动脉扩张率分别为6.90%、3.45%、3.45%,在病程3个月冠状动脉扩张全部恢复正常;在病程2～3周、1个月、2个月、3个月、6个月,对照组冠状动脉扩张率分别为18.75%、12.50%、3.13%、3.13%、3.13%,治疗组较对照组患儿冠状动脉扩张恢复的快,但2组比较差异尚无统计学意义(P>0.05)。结论丹参酮ⅡA联合阿司匹林治疗KD可缩短患儿用药后热退时间,降低CRP水平,一定程度的促进冠状动脉损害修复;用药过程未发现明显的不良反应。
Objective To investigate the treatment effect of Tanshinone Ⅱ A on children with Kawasaki disease. Methods Sixty - one children with Kawasaki disease were recruited in this study. The children were randomly divided into 2 groups ： control group （ IVIG plus aspirin ） and Tanshinone Ⅱ A treatment group. In Tanshinone H A treatment group, apart from IVIG and aspirin , Tanshinone Ⅱ A was administrated intravenously for 5 to 7 days. The changes of clinical symptoms, signs, C - reactive protein level, erythrocyte sedimentation rate and echocardiogram results were recorded and analyzed. Tanshinone H A was applied for 5 to 7 days on the other children. The clinical and physical symp- toms, echocardiograph,level of C - reactive protein and erythrocyte sedimentation rate were observed and studied. Results The level of C - reaction protein decreased significantly and the duration of fever after treatment in Tanshinone 11 A group [ （9. 72± 2. 82 ） mg · L^-1, （ 16.27 ± 3.42） h ] was shorter than that in control group [ （ 14.68 ±2.90） mg · L^-l, （22.78 ± 7.53 ） h ] （Pa 〈 0.05 ） ; and the coronary artery recovered better in Tanshinone fl a group than that in the control group. However, the difference was not statistically significant. Conclu- sions Adding Tanshinone H A to aspirin for the treatment of Kawasaki disease,the duration of fever after treatment becomes shorter and coronary artery injury reconditioned faster in Tanshinone ⅡA group. Tanshinone Ⅱ A which can help coronary artery injury recover,have not been found any adverse effeet.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2011年第21期1645-1647,共3页
Journal of Applied Clinical Pediatrics
关键词
川崎病
丹参酮ⅡA
C反应蛋白
冠状动脉
Kawasaki disease
tanshinone Ⅱ A
C - reactive protein
coronary artery
