摘要
肿瘤细胞与人体正常细胞在代谢上有些不同,这主要体现在能量代谢和物质代谢上。肿瘤细胞能量代谢的特点表现在活跃地摄取葡萄糖和谷胺酰胺,进行有氧糖酵解(Warburg效应)。这种看上去很不经济的能量供给方式对肿瘤细胞却是必需的,它既为肿瘤细胞的不断生长提供能量,也为它们提供了生物合成的原料。肿瘤不同的代谢方式既是挑战也是机遇,弄清肿瘤细胞的代谢机制,对肿瘤早期诊断和靶向治疗具有重要意义。
Cancer cells are different from normal cells in metabolism of energy and matter. Cancer cells take up much more glucose and glutamine for aerobic glycolysis （Warburg effect）. It seems to be wasteful, but is essential for cancer growth in both energy supply and biosynthesis. Altered metabolic phenotypes in cancer are challenges, but also opportunities. Understanding metabolic phenotypes in cancer could lead to new approaches in early diagnosis and target therapy of cancer.
出处
《中国细胞生物学学报》
CAS
CSCD
2011年第10期1158-1165,共8页
Chinese Journal of Cell Biology
