摘要
以大鳞副泥鳅为试验动物,设置甲醛对其急性毒性、遗传毒性和生理毒性试验,研究甲醛对大鳞副泥鳅的半致死浓度、红细胞DNA损伤大小及对其肝脏GPT和GOT活性的影响。结果表明,甲醛对大鳞副泥鳅具有明显的毒性,其96 h的LD50为368.71 mg/L;试验各组的微核率均高于对照组,且与处理浓度和染毒时间呈正相关;同时酶活力与处理浓度和染毒时间则呈负相关。结论:甲醛具有较强的环境毒性,并表现出明显的时间、剂量效应。
Using Paramisgurnus dabryanus as the tested animal,the acute toxicity,genetic toxicity and physiological toxicity tests of formaldehyde were performed to study the effects of formaldehyde on half-lethal concentration,damage of red blood cells and the activity of GPT and GOT in the liver tissue of Paramisgurnus dabryanus.The results showed that formaldehyde had obvious toxicity to Paramisgurnus dabryanus,and its LD50 at 96 hours was 368.71 mg/L.The micronucleus rates in all treatments were higher than that in the control,and they were positively correlated to the test time and test dose of formaldehyde,but the activity of GPT and GOT was negatively correlated to the test time and test dose of formaldehyde.It is concluded that formaldehyde has a strong environmental toxicity,and it shows significant time effect and dose effect.
出处
《江西农业学报》
CAS
2011年第9期143-145,148,共4页
Acta Agriculturae Jiangxi
基金
河南师范大学博士科研启动基金(No.5225441)
国家自然科学基金(3071666)
河南省动物学重点学科项目
关键词
大鳞副泥鳅
甲醛
微核
GPT
GOT
Paramisgurnus dabryanus
Formaldehyde
Micronucleus
GPT
GOT
