摘要
目的 探讨核因子κB（NF-κB）、环氧化酶-2（COX-2）在子宫腺肌病中的表达及意义.方法 应用免疫组化法检测NF-κB、COX-2在正常子宫内膜（对照组）、子宫腺肌病在位子宫内膜（在位内膜组）、异位子宫内膜（异位内膜组）中的表达.结果 NF-κB在子宫腺肌病异位内膜组和在位内膜组的表达均明显高于对照组（P＜0.05）,异位内膜组的表达明显高于在位内膜组（P＜0.05）;COX-2在子宫腺肌病异位内膜组和在位内膜组的表达均明显高于对照组（P＜0.05）,异位内膜组的表达明显高于在位内膜组（P＜0.05）.NF-κB、COX-2在子宫腺肌病异位内膜中的表达呈正相关（r=0.786,P＜0.05）.结论 NF-κB、COX-2在子宫腺肌病的发生发展过程中可能发挥重要作用.
Objective To investigate the expression and significance of nuclear factor κB （ NF - κB） and cyclooxy- genase - 2 （ COX - 2 ） in uterine adenomyosis. Methods The expression of NF - κB and COX - 2 was examined by immnnohistochemical detection of substance P （SP） in normal endometrium （control group）, eutopic endometrium （eutopic group） and eetopie endometrium （eetopic group）. Results NF -κB expression in ectopic group and eutopic group was significantly higher than that in normal group （ P 〈 0.05 ）, and NF - κB expression in ectopie group was significantly higher than that in eutopic group （ P 〈 0.05 ） ; COX - 2 expression in ectopic group and eutopic group was significantly higher than that in normal group （ P 〈 0.05 ） , and COX - 2 expression in ectopic group was significantly higher than that in eutopic group （P 〈 0.05 ）. There was a positive correlation between NF -κB expression and COX - 2 expression in ectopic endometrium in uterine adenomyosis （r = 0.786, P 〈 0. 05）. Conclusion NF - κB and COX - 2 may play important roles in the pathogenesis and progression of uterine adenomyosis,
出处
《徐州医学院学报》
CAS
2011年第2期102-104,共3页
Acta Academiae Medicinae Xuzhou
