摘要
目的探讨2型糖尿病(T2DM)患者早期肾损害中胱抑素C(CYSC)和尿微量白蛋白(mALB)联合检测的必要性和意义。方法选取118例住院2型糖尿病患者用免疫透射比浊法检测糖化血红蛋白(HBA1c),按照HBA1c的高低分为控制良好组(A组)和控制不良组(B组),选取79例健康体检人群作为对照组,用免疫透射比浊法检测CYSC、同时检测尿mALB、Ucr,并进行相关性分析。结果 1.糖尿病组的血清CYSC和尿mALB/Ucr与对照组相比均有显著性差异,且差异具有统计学意义(P<0.05);2.随着尿mALB/Ucr的增高血清CYSC显著增高(P<0.05),且两者呈正相关。3.在糖尿病组中血清CYSC和尿mALB/Ucr均可能单独升高(P<0.05),其中血清CYSC单独升高82例、尿mALB/Ucr单独升高81例,两者联合检测阳性率为76.27%。结论血清CYSC和尿液mALB/Ucr是诊断糖尿病早期肾损害的灵敏指标,临床上结合血清CYSC和尿液mALB/Ucr发现病人早期肾功能改变,能够提高发现糖尿病早期肾损害的敏感性。
Objective To explore the necessity and significance combined detection serum CYSC and mALB in in the type 2 diabetic patients（T2DM） with early renal damage.Methods 118 cases of type 2 diabetes in hospital according to the discretion of HBA1c into good control group（group A） and poor control group（group B）,79 patients healthy check-up crowd as control group,were determined CYSC HBA1c,urine mALB,Ucr,.Results 1.The CYSC and mALB/ Ucr of diabetic group compared with control group are significant difference（P 0.05）.2.mALB/Ucr and CYSC in each group with the relevant analysis shows that with the increase of urinary mALB/Ucr serum CYSC significantly increased（P 0.05）,both were positively correlated.3.In diabetic group CYSC and mALB/Ucr could all alone increased（P 0.05）,Among them CYSC 82 cases,mALB/Ucr 81 cases,combining both tested positie for 76.27%.Conclusion serum CYSC and urine mALB/Ucr is diagnosed with early renal damage with a sensitive index,Through the mALB/Ucr and CYSC found early renal change can improve the sensitivity of early diabetic renal damage
出处
《中国实验诊断学》
北大核心
2011年第10期1666-1668,共3页
Chinese Journal of Laboratory Diagnosis
