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比索洛尔、依那普利和螺内酯联合治疗风湿性心脏病慢性心力衰竭的效果 被引量：22

Effect of enalapril,bisoprolol and spironolactone on chronic heart failure caused by rheumatic heart disease
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摘要 目的:观察比索洛尔、依那普利和螺内酯联合治疗风湿性心脏病(风心病)慢性心力衰竭(心衰,CHF)对心脏重构的影响。方法:风心病并发心衰患者86例,随机分为比索洛尔、依那普利和螺内酯联合治疗组(试药组)以及常规治疗方案对照组(对照组)。在治疗后1年测定心功能与左室内径等指标。结果:试药组左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)显著下降,左室射血分数(LVEF)增加显著,与对照组比较有显著差异(均P<0.05)。结论:比索洛尔、依那普利和螺内酯联合治疗治疗风心病心力衰竭较常规治疗方法在改善心衰,阻止心脏重构方面效果更好。 AIM：To study the effect of enalapril, bisoprolol and spironolactone on chronic heart failure （CHF） caused by rheumatic heart disease （RHD）. METHODS： Eighty six RHD patients with CHF were randomly divided into control group （n=43） and experimental group （n=43）. The experimental group was treated with enalapril, bisoprolol and spironolactone, whereas the control group was treated with a conventional regimen. RESULTS： Left ventricular end-diastolic diameter （LVEDD） and left ventricular end-systolic diameter （LVESD） in the experimental group were significantly lower than in the control group. Left ventricular ejection fraction in the experimental group was much higher （P〈0.05）. CONCLUSION： Combination therapy of enalapril, bisoprolol and spironolactone has a better effect on patients with CHF caused by RHD and inhibits ventricular remodeling.
作者 管一平 邹翰琴
机构地区 宜宾市第二人民医院心内科 宜宾市第二人民医院超声诊断科
出处 《心脏杂志》 CAS 2011年第5期623-625,628,共4页 Chinese Heart Journal
关键词 心脏病 风湿性 心力衰竭 慢性 依那普利 比索洛尔 螺内酯 心脏重构 rheumatic heart disease heart failure enalapril bisoprolol, spironolactone ventricularremodeling
分类号 R541.61 [医药卫生—心血管疾病]
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参考文献8

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心脏杂志
2011年 第5期

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