摘要
目的:探讨正已烷对多发性周围神经损伤的早期影响。方法:160例正己烷产业工人作为研究对象被随机分为实验组(直接接触者)和对照组(非直接接触者),调查两组的作业场所正己烷浓度(采用TWA浓度)、尿中2,5-己二酮浓度、神经行为功能(采用NCTB)和情感功能状态(采用SCL-90)。结果:(1)TWA浓度平均值为(32.54±38.75)mg/m^3。监测点TWA合格率为80%。(2)实验组2,5-己二酮浓度范围为(0.50～5.34)mg/L,对照组为(0.13～0.47)mg/L。两组比较统计学差异具有显著性(t=7.43,P<0.01)。(3)实验组NCTB手提转捷度、简单反应时、目标追踪测试等指标显著差于对照组(P<0.05)(4)实验组SCL-90总分和抑郁、焦虑、躯体化等3组因子得分均显著高于对照组(P<0.05)。结论:正已烷多发性周围神经指标的检测对于预防中毒具有重要意义,但由于正己烷导致的毒性问题有其深刻的社会性,需要各方面的共同努力。
Objective： To explore the influence of n-hexane on multiple of peripheral nerve injury. Methods： 160 cases of n-hexane related worker were randoml3, divided into cxperimemal group （direct toucher） and control group （indirect toucher）. Both groups were detected with such indexes： TWA concentration of n-hcxane, conccntralion of 2. 5-hexancdionc in urine, NCTB and SCL-9OResults：（1） The average TWA concentration was （32.54 ± 38.75）mg/m3,passcd rate of monitoring point was 80%. （2） The concentration of 2,5-hcxancdionc in cxpcrimcntal group was （0.50-5.341mg/L, and in control group was（0.13 -0.47）mg/l., there was significant difference between two group（t =7.43,P〈0.01）.（3） Many indexes of NCTB in experimental group was significant worse than control group （P〈0.05）. （4） Total score and some indexes of SCL-90 in experhncntal group was significant higher than control group （P〈0.05）. Conclusion： Detection of early index of multiple of peripheral nerve injury caused by n-hexane is important on prcvcntion of poisoning, but because of protbund sociality about this problem, it needs commonly hard work from various directions
出处
《中国医药导刊》
2011年第8期1468-1469,共2页
Chinese Journal of Medicinal Guide
