摘要
目的:观察CRP检测在COPD急性加重期中的诊断价值,并与WBC,ESR指标在检测感染阳性率,治疗效果以及疾病预后等方面进行对比,讨论其优势所在及优势机制。方法:选择60例急性加重期慢性阻塞性肺疾病患者,入院即做胸片检查,次日清晨空腹抽取静脉血3ml,测定WBC,ESR,CRP,使用抗生素抗感染7天后再次检测WBC,ESR,CRP等指标,治疗过程中我们根据患者症状辅以使用支气管扩张剂,茶碱以及地塞米松等药物控制呼吸困难,止咳化痰以缓解症状,另外选取COPD缓解期的住院患者作为对照组进行对比研究,主要比较CRP,WBC,ESR指标在检测感染阳性率,治疗效果以及疾病预后的优势。结果:研究组患者经过治疗后CRP降至正常,变化有显著差异(P<0.01),两组治疗后对比CRP浓度(P>0.05),无统计学意义。两组血沉的浓度在治疗后有所下降,统计学上有差异(P<0.05),组间比较无统计学意义(P>0.05),研究组白细胞的变化具有统计学意义(P<0.05),两组治疗后比较具有统计学意义(P<0.05),三种检测指标中CRP的下降幅度具有显著的统计学意义(P<0.01);WBS,ESR治疗后组间检出率具有统计学意义(P<0.05),结论:动态监测血清CRP对于评价AEAECOPD急性加重期患者病情,具有检测阳性率高,不受药物影响并且能够预测预后的临床意义。
Objective：To investigate the value of C-reactive protein（CRP）in patients with chronic obstructive pulmonary disease （COPD）with acute exacerbation.Exacerbation.and CRP, the WBC,ESR indexes compared in the detection rate of infection, treatment effect and disease prognosis,we will Discuss the advantage and advantage mechanism.Methods：60 cases of acute exacerbation of chronic obstructive pulmonary disease period were Selected,They did chest radiograph inspection and they would hollow extraction venous blood 3ml.determine the WBC,ESR,CRP the next morning：They used antibiotic resistance to infection and measured once the WBC,ESR,CRP seven days later.we.according to the patient＇ s symptoms used theophylline and dexamethasone bronchodilators such drug to control breathing difficulties,in order to relieve symptoms and reduce phlegm in the healing process.We selected COPD patients hospitalized in remission of comparative study as control group,and Mainly comparatived CRP, the WBC.ESR indexes in the detection rate of infection,treatment effect and disease prognosis advantage. Results：After receiving treatment group patients came to normal,and change CRP levels have significant difference （P〈0.01）, the two groups after treating contrast,CRP levels （P〉0.05）.no statistical significance. Two groups of Xiechen concentration has dropped,after treatment.statistically have difference （P〈0.05）,compared between groups was not statistically significant （P〉0.05）, the team leucocyte changes are statistically significant （P〈0.05）,two groups compare a Statistically significant after treatment （P〈0.05）,three of the CRP test index declines have significant statistically significant （P〈0.01）;WBS recently, ESR after treatment groups are statistically significant rate （P〈0.05）.Conclusion：Dynamic monitoring for evaluation AEAECOPD serum CRP patients after acute exacerbations period is tall,not tested positie impact and can forecast by drug prognostic clinical significance.
出处
《中国医药导刊》
2011年第7期1240-1242,共3页
Chinese Journal of Medicinal Guide
