摘要
目的观察丹参(SM)加入冷含血心脏停搏液在冠状动脉旁路移植术(CABG)体外循环(ECC)中的心肌保护作用,并探讨其机制。方法 30例ECC下行CABG患者,随机分为观察组(15例)和对照组(15例)。观察组接受加入SM的心脏停搏液,对照组接受未加SM的心脏停搏液。分别观察两组术前、术毕、术后6、24h的血清超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量,乳酸脱氢酶(LDH)、肌酸磷酸激酶同工酶(CK-MB)、心肌肌钙蛋白(cTnI)水平,及患者心脏自动复跳率、激活全血凝固时间(ACT)、呼吸机辅助时间、术后住院天数等。结果观察组术毕、术后6、24hSOD活性高于对照组(P<0.05);MDA、LDH、CK-MB、cTnI值低于对照组(P<0.05),心脏自动复跳率高于对照组,但差异无统计学意义(P>0.05),呼吸机辅助时间、术后住院天数及ACT两组比较,差异无统计学意义(P>0.05)。结论 SM加入心脏停搏液在CABG术ECC中具有明显的心肌保护作用,其心肌保护效果优于未加SM的心脏停搏液组。
Objective To observe the myocardial protection of cardioplegic solution with Salvia miltiorrhizae （SM） in extracorporeal circulation of coronary artery bypass graft （CABG） and to investigate the mechanisms of SM. Methods 30 patients who received CABG under extracorporeal circulation were randomly assigned to two groups, the observation group （15 cases） and the control group （15 cases）. Patients in the observation group received the cardioplegic solution with SM and those in the control group received the cardioplegic solution without SM. The indices such as serum SOD activities, MDA contents, LDH, CK-MB, cTnI levels, the rate of heart re-skip, activated coagulation time （ACT）, the time of assisted respiration, and the days of in-hospital after operation were observed in the two groups pre-operation, post-operation, 6 h and 24 h post-operation, respectively. ResultsWhen compared with the control group, MDA contents, LDH, CK-MB, cTnI levels were lower, SOD activities （all P0.05） and heart re-skip rate （P0.05） higher in the observation group. There was no statistical significance in the time of assisted respiration, the days of in-hospital, or ACT in the two groups （P0.05）. Conclusions The application of cardioplegic solution with SM in extracorporeal circulation of CABG showed obvious myocardial protection. It had better effects than the cardioplegic solution with no SM.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2011年第10期1328-1331,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
黑龙江省中医药科研项目(No.ZHY10-W55)
关键词
丹参
心脏停搏液
冠脉旁路移植术
体外循环
心肌保护
Salvia miltiorrhizae
cardioplegia solution
coronary artery bypass graft
extracorporeal circulation
myocardial protection
