摘要
目的:了解2008～2010年武汉市出生缺陷发生的情况,弄清对出生缺陷发生有影响的相关因素,为进一步研究提供基础。方法:收集武汉市11家省级出生缺陷监测点的产科机构的数据,以上报的出生缺陷儿933例为病例组;从武汉市妇幼信息系统中随机抽取933例于2008～2010年分娩正常新生儿的产妇为对照组,通过出生缺陷报告卡和妇幼信息系统获得相关信息进行统计分析。结果:武汉市2008～2010年出生缺陷的发生率为17.77%,远城区出生缺陷的发生率高于中心城区,差异有统计学意义(P<0.01);产妇年龄<25岁和≥35岁时出生缺陷儿的发生率高于产妇年龄在25岁～35岁产妇的发生率,年龄段之间的差异有统计学意义(P<0.01)。将孕产次、胎儿性别、孕早期患病等11个因素作为自变量进行Logistic回归分析的结果表明孕期常住地址、孕早期患病、有自然流产史进入模型。居住地为远城区、孕早期有病毒感染、妊娠剧吐等病史、既往有自然流产史2次以上提高了出生缺陷的发生风险。结论:应重视出生缺陷发生的一级预防,开展大规模以人群为基础的病例-对照研究,弄清楚引起出生缺陷的流行病学因素,从而制定相应的干预措施,降低出生缺陷的发生。
Objective：To understand the current situation of birth defect in Wuhan city from 2008 to 2010,explore the related effect factors of birth defect,provide a basis for further study. Methods：The data of birth defect were collected from 11 obstetrical institutions in Wuhan,933 infants with birth defect were selected as case group,933 lying-in women who gave birth to normal neonates from 2008 to 2010 were selected from Wuhan MCH information system as control group,the related data were obtained according to report cards of birth defect and MCH information system,then statistical analysis was performed. Results：The incidence of birth defect in Wuhan city from 2008 to 2010 was 17.77%,the incidence of birth defect in remote urban area was significantly higher than that in central urban area（P0.01）;the incidence of birth defect among the lying-in women less than 25 years,equal to and more than 35 years were significantly higher than that among the lying-in women aged 25～35 years old（P0.01）;11 factors,such as gravida,fetal gender,being ill during the first trimester of pregnancy,were used as independent variables for logistic regression analysis,the result showed that permanent address during pregnancy,being ill during the first trimester of pregnancy and spontaneous abortion history were included into the model.Living in remote urban area,viral infection and hyperemesis gravidarum during the first trimester of pregnancy,spontaneous abortion history（more than two times） increased the risk of birth defect. Conclusion：Primary prevention of birth defect should be paid more attention to,large-scale case-control study based on population should be carried out,and the epidemiological factors of birth defect should be understood,in order to adopt corresponding interventional measures and reduce the occurrence of birth defect.
出处
《中国妇幼保健》
CAS
北大核心
2011年第30期4683-4685,共3页
Maternal and Child Health Care of China
关键词
出生缺陷
相关因素
干预措施
Birth defect
Related factor
Interventional measure
