摘要
目的探讨重症监护室(ICU)溶血性葡萄球菌医院感染的危险因素。方法对某综合性三级甲等医院2007—2009年所有发生溶血性葡萄球菌医院感染的ICU患者(28例)进行1:4匹配的病例对照研究,并采用条件Logistic回归分析。结果单因素分析发现基础疾病数、入住ICU天数、住ICU调整天数、抗菌药物使用天数、联合使用抗菌药物、使用广谱抗菌药物、翻身拍背、吸痰、气管插管、使用呼吸机、留置鼻胃管及中心静脉置管与溶血性葡萄球菌医院感染有关。多因素回归分析显示,留置鼻胃管(OR=4.89)、使用呼吸机(OR=5.32)为溶血性葡萄球菌医院感染危险因素,而翻身拍背(OR=0.21)为保护因素。结论合理有效翻身拍背,使用无创通气及减少各种侵入性操作,将有利于预防和控制ICU溶血性葡萄球菌医院感染的发生。
Objective To evaluate the risk factors for nosocomial Staphylococcushaemolyticus （S. haernolyticus） infections （NIs） in intensive care units （ICUs） . Methods A 1 ： 4 matched case-control study was carried out on ICU patients （28 cases） with S. haemolyticus NIs in an integrated hospital between 2007 - 2009. Conditional logis tic regression analysis was adopted. Results Univariate conditional logistic regression analysis showed that S. hae ,~olyticus NIs were related with the number of underlying diseases, days of ICUs stay, adjusted days of ICUs stay, days of antimicrobial use, combination use of antimicrobials , use of broad spectrum antimicrobials , turning over and back patting, sputum aspiration, trachea intubation, use of ventilator, retention of nasogastric tube and central venous catheter. Multivariate logistic regression analysis showed that retention of nasogastric tube（OR = 4. 89） and ventila tor（OR = 5. 32） were risk factors, and turning over and back patting（OR = 0. 21 ）were protective factors. Conclusion Sound and effective practice of turning over and back patting , use of noninvasive ventilation and reducing invasive procedures are helpful for the control and prevention of S. haemolyticus Nls.
出处
《中国感染控制杂志》
CAS
2011年第5期357-360,共4页
Chinese Journal of Infection Control
基金
福建医科大学教授基金(JS06021)
关键词
溶血性葡萄球菌
凝固酶阴性葡萄球菌
医院感染
危险因素
病例对照研究
重症监护室
Staphylococcus haemol yticus
coa gulase-negative Staphylococcus
nosocomial infection
risk factors
case-control study
intensive care unit
