摘要
目的观察马来酸曲美布汀与枯草杆菌二联活菌肠溶胶囊联合对肠易激综合症的疗效及对血清白细胞介素-6(IL-6)的影响。方法收集162例肠易激综合症的患者,依入院顺序,分为观察组与对照组(均81例),对照组口服枯草杆菌二联活菌肠溶胶囊(500 mg,每日3次);观察组口服马来酸曲美布汀(0.1 g)联合枯草杆菌二联活菌肠溶胶囊(500 mg),每日3次,疗程均8周,比较2组疗效及对IL-6的影响。结果治疗后,观察组总有效率明显高于对照组患者;2组IL-6均下降,但是观察组的下降值更明显。结论马来酸曲美布汀联合枯草杆菌二联活菌肠溶胶囊治疗肠易激综合症的效果明显,并能有效调节IL-6的含量。
Objective To observe the curative effect of trimebutine maleate tablets and live combined bacillus subtilis and enterococcus faecium enteric-coated capsules for patients with irritable bowel syndrome and change of interleukin-6（IL-6）.Methods One hundred and sixty-two patients with irrtable bowel syndrome were divided into two groups.The control group（81 cases） were treated by live combined bacillus subtilis and enterococcus faecium enteric-coated capsules treatment（500 mg,three times daily）for 8 weeks,the trial group（81 cases） were treated by trimebutine maleate tablets（0.1 g,three times daily）and live combined bacillus subtilis and enterococcus faecium enteric-coated capsules（500 mg,three times daily）for 8 weeks.The efficacy and the change of IL-6 in two groups were observed.Results The total effective rate in the trial group was obviously higher than in the control group.The change of IL-6 in the trial group were obviously higher after treatment.Conclusion The treatment of trimebutine maleate tablets and live combined bacillus subtilis and enterococcus faecium enteric-coated capsules can improve the curative effect,regulate the expression of IL-6 in patients with irritable bowel syndroe.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2011年第10期743-745,共3页
The Chinese Journal of Clinical Pharmacology
