摘要
目的:比较艾普拉唑与埃索美拉唑三联疗法治疗幽门螺杆菌(Hp)阳性十二指肠溃疡(DU)的近期疗效。方法:120例Hp阳性的DU患者随机分为3组,分别给予艾普拉唑15 mg、20 mg、埃索美拉唑20mg,同时给予克拉霉素0.5g、阿莫西林1.0g,bid,共10d。根除Hp结束后3组患者分别继续给予相应剂量质子泵抑制药治疗4周,于2周末和4周末复查胃镜并检测Hp,观察患者溃疡愈合率、Hp根除率及药品不良反应。结果:2周末3组溃疡愈合率分别为82.5%、75%、77.5%(P>0.05);4周末溃疡愈合率分别为90%、87.5%、87.5%(P>0.05)。3组Hp根除率分别为85%、82.5%、90%(P>0.05)。3组均未见严重不良反应。结论:艾普拉唑三联疗法治疗Hp阳性DU能有效缓解症状,促进溃疡愈合,安全有效,疗效与剂量无明显线性关系,与埃索美拉唑临床疗效差异不明显。
Objective： To compare the effect of ilaprazole- and esomeprazole-based triple therapy regimens on duodenal ulcer with helicobacter pylori（Hp）infection. Method：120 patients with duodenal ulcer with Hp infection were randomly divided into 3 groups, which were treated with ilaprazole＇15, 20 mg and esomeprazole 20 mg separately, and also given clarithromycin 500 mg and amoxicillin 1 000 mg at the same time twice daily for 10 days. After this treatment, all the patients were given the same dosage of corresponding PPI for 4 weeks, the ulcer, re-examined by endoscopy and the Hp, detected. Then the ulcer healing rates and eradication rates of Hp as well as adverse effects of the medication were evaluated and compared. Result：At the end of 2 weeks, the ulcer healing rates of ilaprazole 15, 20 mg and esomeprazole 20 mg were 82.5%, 75%, 77.5% （P 〉0.05）. At the end of 4 weeks, the ulcer healing rates of ilaprazole 15, 20 mg and esomeprazole 20 mg were 90%, 87.5% and 87.5% （ P 〉 0.05 ）. The Hp eradication rates of ilaprazole 15, 20 mg and esomeprazole 20 mg were 85%, 82.5% and 90% （P 〉 0.05 ）. There was no serious adverse reaction. Conclusion： The ilaprazole-based triple therapy could eradicate Hp infection, relieve symptoms and promote duodenal ulcer healing effectively and safely. There was no relationship between the efficacy and the dosage. The result also showed that the differences between ilaprazole and esomeprazole were not significant.
出处
《药物流行病学杂志》
CAS
2011年第10期509-511,共3页
Chinese Journal of Pharmacoepidemiology
