摘要
目的研究奥美拉唑加阿莫西林、甲硝唑治疗幽门螺杆菌阳性十二指肠溃疡的溃疡愈合率及HP根除率。方法经胃镜确诊 ,胃窦部粘膜活检证实有HP感染的活动性十二指肠溃疡 5 1例 ,随机分成治疗组 2 6例 ,奥美拉唑 2 0mg ,2次 /d ,阿莫西林 0 .5g ,3次 /d ,甲硝唑 0 .4g ,3次 /d。对照组 2 5例 ,奥美拉唑 2 0mg ,2次 /d。疗程 2周。疗程结束后 4周复查胃镜和HP。结果两组溃疡愈合率分别为 92 .3%和 88.0 % (P >0 .0 5 ) ,但HP根除率分别为 84.6%和 4.0 % (P <0 .0 5 )。治疗期间两组均有良好的耐受性。结论奥美拉唑加阿莫西林、甲硝唑治疗幽门螺杆菌阳性十二指肠溃疡有较高HP根除率 。
ObjectiveTo study ulcer healing rate and Helicobacter Pylori (HP) eradicable rate of duodenal ulcers with positive HP treated by combining therapy of omeprazole (Ome), amoxicillin (Amx) and metromidazole (Met). MethodsFifty-one patients of clinically active duodenal ulcers with HP infection identified by gastroscopy and mucosal biopsy on gastric antrum were divided at random into two groups: ①26 cases in treated group were given 20 mg Ome, bid; 0.5 g Amx, tid and 0.4 g Met, tid; ②25 cases in control group were given 20 mg Ome bid only. The course of treatment lasted for 2 weeks. Patients of both groups were followed up by gastoscopy and HP detection four weeks later. ResultsHealing rate of duodenal ulcers in ① and ② group was 92.3% and 88.0%, respectively (P>0.05). But HP eradicable rate was 84.6% in the former and 4.0% in the latter (P<0.05). Drugs were well tolerated in both groups.ConclusionsHP eradicable rate of the group treated by triple drugs is favorably higher than that of control group. Triple drugs therapy may perhaps decrease the recurrent rate of duodenal ulcer in the long run and can be preferably selected for its clinical treatment.
出处
《湖南医学》
2001年第4期243-244,共2页
Hunan Medical Journal
