摘要
苦参碱(matrine,Ma)来源于苦豆子Sophora alopecuroides L.)。Ma有加强豚鼠乳头肌收缩的作用,对豚鼠心房亦有明显正性肌力作用。本文对Ma的正性肌力作用与细胞外钙的关系进行了研究。Ma (mp 75.5～77.5℃)为淡黄色粉末结晶,为宁夏盐池制药厂产品。
Matrine (Ma) was extracted from the seed and leaves of Sophora alopecuroides L. Ma showed positive inotropic actions in isolated guines pig left atrium and rat vas deferens under electric stimulation. The positive inotropic actions were markedly inhibited by verapamil (1μmol / L) Isolated rat vas def e rens under the action of Ma showed rhythmic contraction. High K^+ (KCl 40 mmol/ L) augmented the frequency of rhythmic contraction induced by Ma; conversely, Ma may also augment the increased tension produced by high K^+. These results suggest that, the positive inotropic actions of Ma is relevant to its activation of Ca^(2+) channels.
出处
《药学学报》
CAS
CSCD
北大核心
1990年第8期637-639,共3页
Acta Pharmaceutica Sinica
基金
国家自然科学基金
