摘要
目的探讨甲状腺激素与糖尿病类型、病情及病程的关系。方法选择糖尿病患者197例和健康体检者40例,采用电化学发光法测定血清甲状腺激素三碘甲状腺原氨酸(T3)、总甲状腺素(T4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)水平,采用放射免疫法测定甲状腺激素rT3含量,观察糖尿病不同类型、病情、病程分组中T3、T4、FT3、FT4,TSHr、T3含量变化特点。结果 1型和2型糖尿病组T3、FT3、FT4均显著低于健康对照组(P<0.01),rT3均显著高于健康对照组(P<0.01);1型糖尿病组T3、FT3、FT4低于2型糖尿病组(P<0.05),而rT3高于2型糖尿病组(P>0.05)。7%≤糖化血红蛋白(HbA1c)<10%、10%≤HbA1c<13%、HbA1c≥13%3组的T3、FT3和TSH低于HbA1c<7%组(P<0.05或P<0.01)。随着病程延长,T3、FT3呈降低趋势(P<0.05或P<0.01),rT3呈现升高趋势(P<0.05或P<0.01)。结论甲状腺激素水平对糖尿病患者糖代谢的评估、病情估计及预后判断有重要的临床意义。
Objective To explore the relationship between thyroid hormone type,state and course of diseases of diabetes mellitus（DM）.Methods 197 samples of DM and 40 samples of normal controls were selected.Serum thyroid hormones T3,T4,FT3,FT4 and TSH levels were measured with electrochemiluminescence（ECL）.Serum thyroid hormones rT3 levels were measured with Radio Immunoassay（RIA）.Then the variational traits of thyroid hormones T3,T4,FT3,FT4,TSH and rT3 were observed in different groups according to the type,state,and course of diseases of DM.Results The levels of serum T3,FT3 and FT4 in type 1 and 2 DM were significantly lower than those in the control group（P〈0.01）.The level of serum rT3 was significantly higher than that in the control group（P〈0.01）,the levels of serum T3,FT3 and FT4 in type 1 DM were lower than those in type 2 DM（P〈0.05）.The levels of serum rT3 in type 1 DM were higher than those in type 2 DM（P〈0.05）.The levels of serum T3,FT3 and TSH in 7%≤HbA1c10%,10%≤HbA1c13%,HbA1c≥13% were lower than those in HbA1c7%（P〈0.05 or 0.01）.With the course of disease prolonged,the levels of serum T3 and FT3 showed a decreasing tendency（P〈0.05 or 0.01）.The level of serum rT3 showed a increasing tendency（P〈0.05 or 0.01）.Conclusion The levels of serum thyroid hormones have important value in the assessment of the glucose metabolism,the estimation of the cases and the prognosis in diabetic patients.
出处
《检验医学与临床》
CAS
2011年第20期2455-2457,共3页
Laboratory Medicine and Clinic
