摘要
目的探讨超敏C-反应蛋白(hs-CRP)在7种常见肾脏病中的变化。方法通过对近半年来就诊的治疗前的血肌酐正常的狼疮性肾炎(LN1)、紫癜性肾炎(PN)、慢性肾炎(CGN1)、原发性肾病综合征(PNS1),血肌酐升高的糖尿病肾病(DN)、非尿毒症期的慢性肾炎(CRF1)、尿毒症期的慢性肾炎(CRF2)患者和治疗后尿蛋白转阴、血肌酐正常的狼疮性肾炎(LN2)、慢性肾炎(CGN2)、原发性肾病综合征(PNS2)患者及健康体检人群的hs-CRP的测定,总结hs-CRP的变化规律。结果治疗前与正常人群比较,LN1、PN、CGN1、PNS1、CRF1、CRF2和DN组患者CRP水平增高(P<0.05);与CGN1和PNS1组患者比较,LN1和CRF2组患者CRP水平显著升高(P<0.05);DN、CRF1和CRF2组3组间患者CRP水平无统计学意义(P>0.05);CGN1和PNS1组2组间患者CRP水平无统计学意义(P>0.05)。治疗后与正常人群比较,LN2组患者CRP水平仍显著升高(P<0.05),CGN2和PNS2组患者CRP水平无统计学意义(P>0.05);LN2、PNS2组患者CRP水平较治疗前显著降低(P<0.05),CGN2组患者CRP水平较治疗前无统计学意义(P>0.05)。结论在狼疮性肾炎、紫癜性肾炎等7种常见肾脏病中hs-CRP水平较正常人群升高,不同肾脏病的hs-CRP水平还存在差异,尿蛋白转阴并不一定代表炎症反应得到了控制,积极控制炎症反应,可能对预防心脑血管事件的发生具有重要意义。
Objective To investigate high-sensitivity C-reactive protein（hs-CRP） in seven common kidney diseases changes.Methods Through the past six months,hs-CRP of patients with normal serum creatinine（Scr） of lupus nephritis（LN1）,purpura nephritis（PN）,chronic lomerulonephritis（CGN1）,primary nephrotic syndrome（PNS1）,diabetic nephropathy（DN） with Scr increased,chronic glomerulonephritis with Scr increased but non-uremia（CRF1） and chronic glomerulonephritis when uremia（CRF2） before treatment were detected.And hs-CRP of patients with urine protein negative and normal Scr of lupus nephritis（LN2）,chronic glomerulonephritis（CGN2）,primary nephrotic syndrome（PNS2） after treatment and healthy people were detected,the changes of hs-CRP were summarized.Results Compared with the normal population,hs-CRP of LN1,PN,CGN1,PNS1,CRF1,CRF2,and DN groups were increased before treatment（P〈0.05）.Compared with CGN1 and PNS1 groups,hs-CRP of LN1 and CRF2 groups were significantly higher（P〈0.05）.Hs-CRP among the three groups of DN,CRF1 and CRF2 were not significantly different（P〉0.05）.Hs-CRP among CGN1 and PNS1 groups were not significantly different（P〉0.05）.Compared with the normal population,hs-CRP of LN2 group remained significantly elevated after treatment（P〈0.05）,hs-CRP of CGN2 and PNS2 groups were not significantly different（P〉0.05）.Hs-CRP of LN2 and PNS2 groups were significantly reduced after treatment（P〈0.05）,hs-CRP of CGN2 group was not significantly different after treatment（P〉0.05）.Conclusion In seven common kidney diseases such as lupus nephritis,purpura nephritis et al,hs-CRP was increased than the normal population.Hs-CRP in different kidney disease may be different.Urinary protein negative does not mean the inflammatory reaction controled necessarily.Active control of inflammation,may be important to the prevention of blood vessel events.
出处
《医药论坛杂志》
2011年第17期6-8,11,共4页
Journal of Medical Forum
