摘要
弓形虫分布广泛,且人畜感染弓形虫会带来很严重的后果,所以弓形虫病的防治一直困扰着各国学者。近年来,随着对弓形虫研究的深入以及分子生物学的发展,弓形虫核酸疫苗的研究也取得了较大的进展。本文综述了弓形虫主要抗原以及弓形虫核酸疫苗的研究现状,探索弓形虫疫苗的发展前景,并对核酸疫苗的优缺点进行讨论。
Toxoplasma gondii is widely distributed and infection of humans and animals can have very serious consequences,so researchers from various countries have had difficulty preventing and treating toxoplasmosis.In recent years,T.gondii DNA vaccines have made considerable progress with in-depth study of T.gondii and advances in molecular biology.This paper reviews the state of development of DNA vaccines for T.gondii utilizing its major membrane antigens.This paper also explores prospects for the development of T.gondii vaccines and it discusses the advantages and disadvantages of DNA vaccines.
出处
《中国病原生物学杂志》
CSCD
2011年第9期697-701,共5页
Journal of Pathogen Biology
基金
国家自然科学基金项目(No.81071373)
山东省自然科学基金项目(No.ZR2009CM079)
家畜疫病病原生物学国家重点实验室开放基金课题(No.SKLVEB2011KFKT005)
关键词
弓形虫病
表面抗原
核酸疫苗
综述
Toxoplasmosis
surface antigen
DNA vaccine
review
