摘要
以咪唑为原料,经过苯甲酰化、选择性脱酰基、加氢还原、酸水解、还原胺化和成盐等六步化学反应得到2-二乙胺基甲基咪唑盐酸盐,总收率为45%.所得中间体及产物均经核磁共振氢谱和核磁共振碳谱进行结构确证.
The paper describes the new method for synthesis of the compound starting from commercially available imidazole, which contains six steps including benzoylation, selective debenzoylation, hydrogenation, acidic hydrolysis, reductive amination and salification. The total yield based on imidazole is over 45 %. The structures of all intermediates and product were confirmed by ^1H and ^13C NMR spectral analysis.
出处
《河南科学》
2011年第10期1172-1174,共3页
Henan Science
基金
国家自然科学基金(81072539)
