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地佐辛超前镇痛用于无痛人工流产术的临床研究 被引量:12

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摘要 目的观察静脉注射地佐辛超前镇痛对丙泊酚复合芬太尼无痛人工流产术中及术后疼痛的影响。方法选择自愿终止妊娠且无麻醉禁忌证的早孕妇女70例,随机分为地佐辛组和对照组,术前10 min两组分别静推地佐辛0.2 mg/kg,或安慰剂(生理盐水)2 ml。两组均在小剂量丙泊酚复合芬太尼静脉麻醉下行无痛人工流产术,记录丙泊酚用量、术中呼吸和循环监测指标、丙泊酚引起注射痛、意识恢复时间、自由对答时间、苏醒时、苏醒后5 min、15 min及30 mm宫缩痛及VAS评分。结果两组患者麻醉诱导时间、手术时间以及不同时间点MBP、RR、HR和SpO_2比较差异无统计学意义(P>0.05),地佐辛组丙泊酚用量较对照组减少,差异有统计学意义(P<0.05),地佐辛组和对照组注射痛VAS评分分别为(2.3±1.1)分和(6.5±1.9)分;患者清醒后不同时间点VRS口述痛觉评分对照组均较地佐辛组高,差异有统计学意义(P<0.05);两组均未见严重不良反应。结论地佐辛超前镇痛可显著降低丙泊酚复合芬太尼无痛人工流产术注射痛及苏醒期宫缩痛的发生率和疼痛程度,减少丙泊酚用量,且不增加呼吸抑制等不良反应的发生率。
出处 《中国医学创新》 CAS 2011年第27期19-20,共2页 Medical Innovation of China
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