摘要
目的:探讨宫颈细胞DNA定量分析结合液基细胞学诊断方法进行宫颈癌筛查的临床意义。方法:对2009年10月～2010年4月参加我院宫颈癌筛查的5 886例妇女,进行液基细胞学检查和细胞DNA定量分析诊断,在细胞学诊断≥低度鳞状上皮内病变或细胞DNA分析有≥3个异倍体细胞,建议做宫颈病理组织学活检,以病理诊断结果为标准。结果:液基细胞学诊断阳性285例,阳性率为4.84%(285/5 886);细胞DNA异倍体检出阳性486例,检出率为8.25%(486/5 886);细胞DNA定量分析结合液基细胞学诊断检出阳性525例,总阳性率为8.92%(525/5 886)。525例患者需做宫颈组织活检,活检结果:阳性375例,阳性率为71.4%(375/525)。结论:细胞DNA定量分析结合液基细胞学诊断方法,能明显提高宫颈癌筛查阳性检出率。
Objective： To discuss the clinical significance of quantitative analysis of cellular DNA combined with liquid-based cytology in cervical cancer screening.Methods： 5 886 cases attending cervical cancer screening from October 2009 to April 2010 in our hospital were given quantitative analysis of cellular DNA and liquid-based cytology.The cases whose results exceeding LSIL in cytological diagnosis or exceeding 3 heteroploid cells in quantitative analysis of cellular DNA were suggested to make a biopsy of histopathology of cervical cellular,with the results of pathological diagnosis as a standard.Results： 285 cases were diagnosed positive by liquid-based cytology and 486 cases were diagnosed positive by quantitative analysis of cellular DNA,each positive diagnosis rate was 4.84%（285/5 886） and 8.25%（486/5 886）.525 cases were diagnosed positive by quantitative analysis of cellular DNA and liquid-based cytology,the positive diagnosis rate of which was 8.92%（525/5 886）.525 cases were made biopsyofcervix,among which,375 cases were diagnosed positive,the positive diagnosis rate was 71.4%（375/525）.Conclusion： Quantitative analysis of cellular DNA combined with liquid-based cytology can enhance the positive rate of cervical cancer screening obviously
出处
《中国医药导报》
CAS
2011年第27期75-76,78,共3页
China Medical Herald
关键词
细胞DNA定量分析
液基细胞
宫颈癌筛查
Quantitative analysis of cellular DNA
Liquid-based cytology
Cervical cancer screening
