摘要
目的:探讨对老年慢性失眠症的有效治疗方法。方法:用随机对照方法,将120例老年慢性失眠症患者按随机数字表法分为奥氮平组和阿普唑仑组,治疗4周。采用匹兹堡睡眠质量指数(pittsburgh sleep quality index,PSQI)及药物不良反应量表评定临床疗效和不良反应。结果:奥氮平组在治疗第四周时PSQI总分、汉密顿焦虑量表(Hamilton anxiety scale,HAMA)、汉密顿抑郁量表(Hamilton depression raling scale,HAMD)、临床显效率分别为(5.2±1.8)分、(11.5±5.4)分、(5.1±2.3)分、91.7%,明显优于阿普唑仑组(6.8±2.5)分、(17.5±7.8)分、(9.9±5.8)分、68.3%,差异具有显著性(P<0.05)。结论:低剂量奥氮平不仅能显著改善慢性失眠症患者的睡眠状况,而且可以明显减少患者日常功能的缺失。
Objective：To study the effective treatment of elderly chronic insomnia.Methods：Using randomized controlled methods,120 cases of elderly chronic insomnia were randomly divided into olanzapine group and alprazolam group.The Pittsburgh Sleep Quality Index（PSQI） and drug side-effects scale were adopted to evaluate the clinical efficacy and adverse reactions after 4-week treatment.Results：The PSQI total score,Hamilton Anxiety Scale（HAMD）,Hamilton Depression Rating Scale（HAMA） and the clinical excellent effective rate after 4-week treatment in olanzapine group were 5.2±1.8,11.5±5.4,5.1±2.3 and 91.7% and significantly superior to 6.8±2.5,17.5±7.8,9.9 ± 5.8 and 68.3% in alprazolam group respectively,showing significant differences（P0.05）.Conclusion：Low-dose olanzapine not only significantly improves sleep status,but also significantly reduces the daily function missing in the patients with elderly chronic insomnia.
出处
《现代医药卫生》
2011年第17期2590-2592,共3页
Journal of Modern Medicine & Health
