摘要
设计了基于分子印迹与电化学微传感器的尿素仿生微传感器,采用MEMS工艺制作集成微型3电极系统,实现了传感器的微型化.通过电化学方法制备了分子印迹聚合物(MIP),印证了分子印迹聚合物的印迹效果.比较了3支传感器的响应曲线,得到了相近的灵敏度,灵敏度在0.10μA/(μmol.L-1)左右,线性度达到了0.95,检测下限为1.00μmol/mL,分析尿素溶液的标准偏差小于5%,达到和接近临床分析要求,为生物传感器向仿生生物传感器发展进行了具有临床意义的尝试.
A biomimetic microsensor for urea was designed based on molecular imprinting and electrochemical detection, and the integrated electrodes of the sensor were fabricated in MEMS process for realization of miniaturization. The molecular imprinting polymer （MIP） was prepared through electro-polymerization, and its imprinting effect was verified. The response curves of three sensors were compared, showing that they have similar sensitivities around 0. 10 μA / （μmol · L^-1）, linearity of 0. 95, and the detection limitation of 1.00 μmol/mL. The standard deviation in urea solution analysis is less than 5% , which is up to or close to the requirement for clinical application. The proposed sensor is a satisfactory development from bio-sensors to biomimetic sensors.
出处
《纳米技术与精密工程》
EI
CAS
CSCD
2011年第5期417-421,共5页
Nanotechnology and Precision Engineering
基金
国家自然科学基金资助项目(60672019)
关键词
分子印迹
计时电流法
微电极
电化学聚合
molecular imprinting
chronoamperometry
micro-electrode
electro-polymerization
