摘要
本文对老年和非老年人静滴庆大霉素240mg/d进行了血药浓度测定。结果老年人伴有肾功能不全或心衰者,最高血药浓度明显增高(12.41±1.1μg/ml),药物在体内消除缓慢,T_(1/2)明显延长,易发生毒性反应。因此我们认为对于老年人或(和)心、肾功能不全者不宜静滴240mg/d,应予减量,可采用部分量静滴、部分量夜间肌注的方法。
Gentamicins were given by intravenous drip 240 mg/d to the aged(>60yr) and the other patients(<60yr). The serum concentration obviously increased(12.4+ 1.1ug/ml)in the aged and patients with cardiac insufficiency or renal insufficiency. The clearance rate of gentamicins decreased and the T1/2 was prolonged. Therefore the intravenous drip of gentamicins 240 mg/d is not suited to these patients. The dose should be reduced or admidistered partly by intravenous infusion and partly by intramuscular injection at night.
出处
《新药与临床》
CSCD
北大核心
1990年第4期227-228,共2页
关键词
庆大霉素
尿路感染
药物动力学
gentamicins/pharmacokinetics
aged
urinary tract infections/drug therapy
