摘要
近年来试用黄体生成素释放激素-A(LHRH-A)对卵巢功能可起到良好的药物切除作用。本文应用国产LHRH-A^1治疗子宫向膜异位症41例。按美国生育委员会(AFS)标准分类:有Ⅰ级者19例,Ⅱ级者17例,Ⅲ级者5例。按痛经症状分,有原发性痛经26例、继发性痛经8例、不规则阴道流血2例。自月经d2(第2天)开始肌注LHRH-A200μg(或500μg)qd,继续3-6mo。结果痛经消失者31例(91％)。实验室观察16例在治疗前、中、后的E_2与P水平发现,治疗前15例有排卵。排卵在治疗时受抑制的15例与治疗后的15例均可恢复排卵。本组在治疗3mo后妊娠的有5例,其中4例已分娩,1例流产。
Recently the synthesized LHRH-analog (LHRH-A) used as medical oo-phorectomy for treatment of endometriosis offers much promising results. From Jan 1986 to Apr 1988, there were 41 patients of endometriosis treated with LHRH-A in our clinic.According to the AFS score, 19 patients Avere in grade I , 17 patients in grade I and 5 patients in grade I .The chief complains were primary dysmencr-rhea(26 patients).,secondary dysmenorrhea(8 patients)and 2 patients showed irregular vaginal bleeding.LHRH-A 200ug or 500ug im qd from the second day of menstrual peroid for 3 to 6 mo.The cyclic abdominal pain was relieved in 31 patients (91%).Serum estradiol and progesterone were measured by RIA before, during and after treatment in 16 patients. Fifteen patients showed normal ovulation before treatment. During treatment, cyclic serum estradiol and progesterone fluctuations fell to the castrate range, while menstruation resumed after the treatment was withdrawn.The estradiol and progesterone rose again to the level same as those of ovulatory cycle. Five patients became pregnant 3 mo after treatment, 3 patients in grade 1,2 patients in grade I . Four patients delivered at full term,l patient aborted.
出处
《新药与临床》
CSCD
北大核心
1990年第3期176-179,共4页
关键词
LHRH-A
子宫内膜异位
LH-FSH releasing hormone/therapeutic use
danazol/therapeutic use
endometriosis/drug therapy
