摘要
本文应用遗传毒理学检测系统之一——哺乳类动物细胞染色体畸变,对四种临床常用的抗包虫化疗药物致变性作了比较研究。结果:四种抗包虫化疗药物所致染色体畸变率由大至小依次为甲苯咪唑(MBZ)、氟苯咪唑(FBZ)、吡喹酮(PZQ)及丙硫咪唑(ABZ)。其中只有甲苯咪唑所致染色体畸变率高于阳性对照组,为致变阳性;其余三者均无肯定致变性。根据我们的实验结果并结合文献报道,建议在包虫病的治疗中以首选丙硫咪唑为佳,尽量避免应用甲苯咪唑。
We studied the mutagenicities of four anti-hydatid drugs MBZ,PZQ,ABZ,and FBZ,by using the mammalian cell line established from grey hamster in our laboratory in 1985.The drugs were added into the cultures of the cell line separately at the final concentrations 10^(-5)M,10^(-6)M,and the cells were treated for 48 hours.The results showed that MBZ caused the increase of chromosomal aberration incidence obvi- ously(higher than the positive control),and the chromosomal aberration differences between other three drugs and the negative control were not significant.It is to be sure that three of the four anti-hydatid drugs, PZQ,ABZ,and FBZ,are not mutagens in our experiments.This study provides references for selection of safer drugs in the treatment of human hydatidosis.
关键词
抗包虫药
致变性
吡喹酮
甲苯咪唑
praziquantel
mebendazole
flubendazloe
albendazole
anti-hydatid drugs
mutagenicity
mammalian cell
chromosomal aberration incidence
