摘要
在西方国家和我国,非酒精性脂肪肝病(NAFLD)是公认的最常见的慢性肝病类型,也是重要的隐源性肝硬化的主要原因。胰岛素抵抗是NAFLD的重要发病机制,同时已将NAFLD作为代谢异常综合征诊断标准的辅助部分。研究表明,细胞因子通过多个复杂的环节,不仅直接参与"第一次打击"脂肪肝的形成,而且在"第二次打击"脂肪性肝炎、肝纤维化、肝硬化的启动、发生和进展中起重要作用。现主要讨论:肿瘤坏死因子α、核因子κB、脂联素、瘦素与肝损伤、肝纤维化的关系。
In western countries and China,non-alcoholic fatty liver disease（NAFLD）is recognized as the most common type of chronic liver disease,which is also the important main reason for cryptogenic cirrhosis.Insulin resistance is an important pathogenesis of NAFLD,and meanwhile has put NAFLD the auxiliary parts as diagnosis standard of metabolic abnormalities syndrome.Studies have shown that cytokines through multiple complex aspects,not only directly involved in the ＂first blow＂ the formation of fatty liver,but also play an important role in the start-up,occurrence and progression of the ＂second blow＂ steatohepatitis,liver fibrosis and cirrhosis.This paper mainly discusses the relationship of liver damage,liver fibrosis and tumor necrosis factor-α,nuclear factor κB,adiponectin,leptin.
出处
《医学综述》
2011年第16期2421-2423,共3页
Medical Recapitulate
