摘要
目的检测妇科肿瘤术后下肢深静脉血栓形成的患者血浆中组织因子(TF)、组织因子途径抑制物(TFPI-1)水平的变化,探讨其与妇科肿瘤术后深静脉血栓形成的相关性。方法用ELISA法分别检测妇科良恶性肿瘤术后患者血浆TF、TFPI-1水平的变化。结果无深静脉血栓形成的妇科恶性肿瘤组TF水平显著高于子宫肌瘤及健康对照组(P<0.01),妇科恶性肿瘤组TFPI-1水平高于子宫肌瘤及健康对照组(P<0.05),子宫肌瘤与健康对照组比较差异无统计学意义(P>0.05)。深静脉血栓形成妇科恶性肿瘤组TF水平显著高于子宫肌瘤及健康对照组(P<0.01),有深静脉血栓形成妇科恶性肿瘤组TFPI-1水平与无深静脉血栓形成妇科恶性肿瘤组相比之间无统计学差异(P>0.05),子宫肌瘤与健康对照组比较差异无统计学意义(P>0.05)。结论妇科肿瘤术后深静脉血栓形成患者组织因子明显增高,TF、TFPI-1可作为检测妇科肿瘤尤其是妇科恶性肿瘤术后深静脉血栓形成的重要指标。
Objective To investigate the relationship between tissue factor （TF）,tissue factor pathway inhibitor （TFPI-1） and postoperative deep venous thrombosis in patients with gynecological tumors by measuring the plasma levels of TF and TFPI-1. Methods Seventy two patients with gynecological tumors were enrolled and the plasma levels of TF and TFPI-1 antigen were measured by ELISA method. Results Of no deep vein thrombosis groups, the plasma levels of TF in gynecological tumors group were significantly higher than that of uterine myomas and healthy controls （P 〈 0.01 ）, gynecological tumors group TFPI-1 levels were higher than that of uterine myomas and healthy control group （ P 〈 0.05 ）, uterine myomas compared with the healthy control group were no significant difference （ P 〉 0.05 ）. Of deep vein thrombosis groups, TF of gynecological malignant tumor group were significantly higher than that of uterine myomas group and the healthy control group （ P 〈 0.01 ）, TFPI-1 levels of deep vein thrombosis with gynecological malignant tumors and no deep vein thrombosis of gynecological malignant tumor group were no significant difference （ P 〉 0.05 ）, TFPI-1 level were no significantly difference between uterine myomas and healthy control group （P 〉 0.05 ）. Conclusion TF and TFPI-1 of gynecologic tumors patients with postoperative deep venous thrombosis are significantly higher, and they can be used as indicators for gynecologic malignant gynecological tumors, especially postoperative deep venous thrombosis.
出处
《中国现代医生》
2011年第25期61-62,66,共3页
China Modern Doctor
