摘要
目的评价白子菜水提物对高血压诱导的组织器官损伤的保护作用。方法根据基础血压将40只SHR大鼠分成5组:空白对照组(蒸馏水)、阳性对照组(卡托普利,25 mg/kg)、白子菜水提物高、中、低剂量组(2 g生药/kg1、g生药/kg、0.5 g生药/kg),每天灌胃给药,持续7周,每周称重并记录心率1次,第7周末,通过肉眼和显微观察各鼠心、脑、肾和脾脏的外观或病理变化并予以分级评分。结果经过7周实验,与空白组比较,白子菜高、中剂量组均能明显抑制心肌细胞肥大和肾小球(管)萎缩或代偿性肥大(P<0.01)。高剂量组能显著改善脾脏中央动脉硬化变性现象(P<0.05),降低左室壁厚/右室壁厚,增加肾皮质厚/肾髓质厚(P<0.05)。而低剂量仅对肾脏病理改变有显著保护作用(P<0.05)。结论白子菜提取物对高血压引起的主要器官损伤具有明显的保护作用。
AIM To evaluate the protective effect of water extract of Gynura divaricata on hypertension-induced target organs damage in spontaneous hypertensive rats.METHODS According to baseline blood pressure,forty SHR rats were randomly divided into five groups： control group（distilled water）,captopril group（125 mg/kg）,three water extract of Gynura divaricata groups（low,middle and high dose）.Each rat was administered i.g respectively for 7 weeks.Body weight and heart rate were measured by tail-cuff technique on each weekend.At the end of the 7th weekend,the damage scoring of the heart,brain,kidney and spleen of each rat was performed according to both gross observation and light microscopic evaluation.RESULTS After 7 weeks’ treatment,comparing with control group,the pathological phenomenon of cardiac muscle cell hypertrophy,renal tubule atrophy or compensatory hypertrophy were inhibited,central artery of spleen sclerotic degeneration was scarcely seen in the high dose group（P〈0.05）,the thickness ratio of left ventricular to right ventricular decreased and the thickness ratio of kidney cortex to kidney medulla increased in the high dose group（P〈0.05）.there was also significant difference in renal pathological change in the low dose group.CONCLUSION Gynura divaricata extract could obviously prevent and cure the hypertension-induced target organs damage in rats.
出处
《中成药》
CAS
CSCD
北大核心
2011年第8期1303-1307,共5页
Chinese Traditional Patent Medicine
基金
广西中医药管理局资助项目(GZKZ09-17)
关键词
白子菜
高血压诱导的器官损伤
保护作用
Gynura divaricata（ L. ）DC.
hypertension-induced organ damage
protective effect
