摘要
免疫系统变化在子宫内膜异位症(EMs)发病机制中具有重要病理生理学意义。在免疫反应中,树突状细胞(DC)是目前发现的功能最强的抗原提呈细胞,是体内介导先天性及获得性免疫反应发生的重要细胞之一。EMs患者体内DC数量变化及功能改变引起免疫反应出现异常或缺陷,进而导致异位病灶发生发展。综述有关DC在EMs发病机制中作用的近年文献发现,DC在异位和在位内膜及腹腔液中数量均发生变化,且其功能除抗原提呈能力改变外,还具有促血管和神经生成的作用。DC的各种变化在异位子宫内膜细胞黏附、种植、蔓延发展及免疫耐受的过程中发挥重要作用,对其各种病理生理机制的研究将为预防和治疗EMs开辟新思路。
Immune system alteration plays a central role in the pathogenesis of endometriosis（EMs）. Dendritic cells（DCs）,one of the most important immune cells in the immune system, are key antigen-presenting cells （APC）,which can bridge innate and adaptive immunity to help initiate immune response. The alteration of DCs population and function contribute to the abnormal immunity and defective immune surveillance mechanism, which lead to the development of ectopic endometrial cells. The role DCs play in the pathogenesis of EMs was summarized in this review. The alteration of DCs population was found either in ectopic lesion or in eutopic endometrium and peritoneal fluid. The function of DCs, besides antigen-presenting, promoting angiogenesis and supporting the growth of nerve fiber were reported by literatures. In words, alterations in DCs play a significant role in the immunotolerance and the development of ectopic lesions,so the cellular and molecular mechanisms involved in endometriosis is need to be an in-depth understanding, which may provide a potential therapeutic approach for endometriosis.
出处
《国际妇产科学杂志》
CAS
2011年第4期271-274,共4页
Journal of International Obstetrics and Gynecology
