摘要
[方法]以1,1,3,3-四甲氧基丙烷和尿素为起始原料,通过合环、硝化和氯代反应得到2-氯-5-硝基嘧啶,探讨了合成关键中间体的影响因素。[结果]经过实验确定了理想的反应条件,产物的结构经过1H NMR鉴定进行表征。[结论]该工艺具有收率高、操作简单、安全可靠的特点并且为工业化生产提供参考。
[Methods] 1,1,3,3-Tetramethoxypropane and urea were used as starting material to give the 2-chloro-5- nitropyrimidine by cyclization, nitration and chlorination. The effect factors synthesizing the key intermediate were discussed. [Results] The ideal conditions were determined by experiments, and their structures were confirmed by 1↑H NMR. [Conclusions] The synthetic process has advantages of high yield, simple operation and safety and is important directive to industrialized production.
出处
《农药》
CAS
北大核心
2011年第9期641-642,共2页
Agrochemicals
