摘要
目的观察乌司他汀对重症肺炎患者的肺保护作用,及对住院时间和住院费用的影响。方法将115例急性重症肺炎患者分为乌司他汀治疗组和对照组。对照组进行常规治疗,治疗组在进行常规治疗基础上加用乌司他汀,对比2组患者的临床疗效,治疗前、治疗后第7天C反应蛋白(CRP)、血气、胸片、体温(T)、呼吸(RR)、心率(HR)、血白细胞(WBC)、氧合指数(PaO2/F iO2)、临床肺部感染评分(CPIS)、APACHE-II评分、住院时间及住院费用等。结果治疗组CRP、T、RR、HR、WBC、PaO2/F iO2、CPIS、APACHE-II改善情况明显优于对照组(P<0.05);2组总有效率分别为89.3%、66.1%,差异有统计学意义(P<0.05);治疗组ICU住院时间少于对照组,住院费用减少,差异有统计学意义(P<0.05)。结论乌司他丁辅助治疗重症肺炎患者,可有效减轻患者病情,改善各项炎症指标及氧合指数,减少ICU住院时间,降低住院费用。
Objective To study the lung protection of Ulinastatin（UST） in the patients with severe pneumonia,and influence of time in ICU and expenses led by its application.Method 115 acute severe pneumonia patients were divided into the treatment group and control group.The control group was treated with routine treatment,and the treatment group on the basis of conventional therapy was added Ulinastatin 200 000 U,q8h.The patients clinical conditions,blood gas,oxygenation index（PaO2/FiO2）,T,RR,HR,WBC,chest x-xay,CPIS,APACHE-II score,on before treatment and on the 7th day after treatment were observed.Result The chang of T,RR,HR,WBC,CRP,PaO2/FiO2,CPIS and APACHE-II score in UST treatment group were significantly better than those in the control group（P〈0.05）;the total effective rate of the two groups were 89.3% and 66.1%,which had signicant difference（P〈0.05）;Moreover,there was obvious difference between two groups in the total time in ICU and the expenses in hospital（P〈0.05）.Conclusion Ulinastatin in the treatment of patients with severe pneumonia,can effectively alleviate the severe pneumonia,improve the inflammatory reaction,oxygenation index,and significantly reduce the total time in ICU and the expenses in hospital.
出处
《中国微生态学杂志》
CAS
CSCD
2011年第8期731-733,共3页
Chinese Journal of Microecology
关键词
乌司他汀
重症肺炎
炎症反应
肺损伤
Ulinastatin
Severe pneumonia
Inflammatory reaction
Pulmonary injury
