摘要
目的合成一系列新的甘氨酸衍生物,并初步筛选其抗血小板聚集活性。方法以川芎嗪、甘氨酸、阿魏酸等芳酸为起始原料,经过一系列反应,合成得到目标化合物。结果合成了6个川芎嗪芳酸醚类甘氨酸衍生物,其结构均经IR、1H-NMR、13C-NMR和MS确证。结论所有目标化合物均未见文献报道。药理结果初步显示化合物1a、1b、1c、1d、1e、1f血小板抑制率分别为8.2%、6.5%、15.9%、6.7%、5.1%、3.2%。
Aim To synthesize a series of new glycine derivatives and to study their inhibitory effects on platelet aggregation.Methods The target compounds were synthesized from Ligustrazine,glycine,ferulic acid and its analogs via a series of reactions.Results Six target compounds were synthesized.Their structures were characterized by IR,1H-NMR,13C-NMR and MS.Conclusions The target compounds have not been reported in literatures.Preliminary pharmacological results show that the inhibitory effect on platelet aggregation of compounds 1a,1b,1c,1d,1e,1f is 8.2%,6.5%,15.9%,6.7%,5.1%,and 3.2%.
出处
《安徽医药》
CAS
2011年第8期937-940,共4页
Anhui Medical and Pharmaceutical Journal
基金
国家科技重大专项重大新药创制项目(批准号:2009ZX09103-123)
安徽省高校自然基金重点项目(批准号:KJ2010A206)
关键词
川芎嗪
甘氨酸
抗血小板聚集
化学合成
ligustrazine
glycine
platelet aggregation inhibitory
synthesis
