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淋巴结内外弥漫大B细胞性淋巴瘤分化特征分析

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摘要 目的探讨淋巴结内、外弥漫性大B细胞性淋巴瘤(DLBCL)的分化特点。方法收集108例DLBCL的临床病理资料,结内56例,结外52例,应用免疫组织化学方法检测CD10、Bcl-6、Mum-1和LMP-1的表达,对淋巴结内、外DLBCL瘤细胞分化特征及与EBV的关系进行分析。结果结内组以生发中心型(GCB)分化多见,GCB-DLBCL和非GCB-DLBCL分别占60.7%和39.3%;结外组以非GCB分化多见,GCB-DLBCL和非GCB-DLBCL分别占40.4%和59.6%,两者差异有统计学意义(P<0.05);临床分期Ⅲ～Ⅳ期者共59例,其中结内组29例,结外组30例,其临床分期与结内、外及GCB和非GCB分化无关(P>0.05)。108例DLBCL无一例表达LMP-1蛋白。结论淋巴结DLBCL分化方向以GCB型多见,而结外DLBCL分化方向以非GCB型多见;淋巴结内外DLBCL均无LMP-1表达。
作者 王明华 翁阳 罗志飞 吴媛媛 王林海
机构地区 海南医学院附属医院病理科
出处 《广东医学》 CAS CSCD 北大核心 2011年第16期2183-2185,共3页 Guangdong Medical Journal
基金 海南省自然科学基金资助项目(编号:309037)
关键词 淋巴瘤 弥漫性大B细胞性淋巴瘤 免疫表型
分类号 R733.4 [医药卫生—肿瘤]
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参考文献10

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二级参考文献8

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共引文献9

广东医学
2011年 第16期

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