摘要
目的探讨子宫内膜弥漫性大B细胞性淋巴瘤的临床病理特征及鉴别诊断要点。方法对1例子宫内膜弥漫性大B细胞性淋巴瘤进行临床病理检查,标本采用常规石蜡切片,HE和免疫组化染色,透射电镜观察,并复习相关文献。结果镜下可见病变组织中主要为中心细胞样和中心母细胞样形态的肿瘤细胞。免疫组化显示瘤细胞LCA、CD20、CD79α、lambda(),Ki-67阳性率为80%。电镜下肿瘤细胞数量多,排列紧密,体积较大,核大呈卵圆形,异染色质较多、边集,胞质内细胞器较少。结论发生于子宫内膜的恶性淋巴瘤很少见,该肿瘤的诊断和鉴别诊断主要依靠病理组织学和免疫组化。
Objective To investigate the clinicopathologic features and differential diagnosis of diffuse large B-cell lymphoma （DLBCL） in endometrium. Methods A case of endometrial DLBCL was examined with conventional histopathologic method, and the tumor tissue was studied by using paraffin sections, H-E staining, and immunohistochemical analysis and observed under transmisson electronic microscope simultaneously, followed by discussion through review of the relevant literature. Results By light microscopy, a large number of turner cells were similar to centrocytes and centroblasts in visible lesions. By electron microscopy, the tumor cells were closely spaced, and large in size; the nucleus was big and oval, enchromatin was condensed, gathered at the edge, and the organelles were less in the cytoplasm. Immunohistochemically, the tumor cells were positive for LCA, CD79α, CD20, Ki-67 and Lambda.
出处
《诊断病理学杂志》
CSCD
北大核心
2013年第2期101-103,共3页
Chinese Journal of Diagnostic Pathology
