摘要
目的观察顺阿曲库胺不同给药方式对正常家兔运动诱发电位的影响。方法选正常新西兰大白兔30只,随机分为3组,每组10只,分别经静脉给予顺阿曲库胺。A组为单次静脉注射0.08 mg/kg;B组分次静脉注射,第1次0.04 mg/kg,30 min后0.04 mg/kg;C组微量泵持续泵入0.06 mg/(kg.h)。分别记录给药前(T0)、给药后10 min(T1)、30 min(T2)、50 min(T3)、60 min(T4)和90 min(T5)时家兔下肢运动诱发电位。结果 A、B两组家兔于用药后10 min运动诱发电位潜伏期延长,波幅下降,直至消失,但A组于用药后50～60 min恢复,B组家兔直到实验结束均未记录到运动诱发电位;C组自始至终均成功记录到运动诱发电位。结论用微量泵持续静脉泵入顺阿曲库胺优于单次静脉注射,较易成功监测家兔运动诱发电位。
Objective To evaluate the effects of different methods of cis - atracurium administration on motor evoked potential （MEP） in rabbits. Methods Thirty normal New Zealand rabbits were randomized into 3 groups （ n = 10） according to administration of cis - atracurium： Group A （ bolus intravenous injection of 0. 08 mg/kg）, Group B （ initial intravenous injection of 0. 04 mg/kg with another 0.04 mg/kg half an hour later）, and Group C （ intravenous micro - pump by 0. 06 mg/kg·h）. MEP in lower limb of each subject was recorded before administration （ T0 ）, 10 min（ T1 ）, 30 min （T2 ）, 50 min（ T3 ）, 60 min（ T4 ） and 90 min（ T5 ） alter administration. Results Although prolonged latency and amplitude reduction of MEP were observed in Group A and B, MEP recovery was revealed in Group A 50 - 60 min after administration. However, no recovery was found in Group B throughout the experiment. Meanwhile, MEP was integrated in Group C throughout the experiment. Conclusion Continuous intravenous micro - pump of eis - atracurium is superior to bolus injection in MEP monitoring of rabbits.
出处
《广东医学》
CAS
CSCD
北大核心
2011年第16期2101-2104,共4页
Guangdong Medical Journal
关键词
顺阿曲库胺
运动诱发电位
兔子
cis - atracurium
motor evoked potential
rabbit
