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非小细胞肺癌术前辅助性化疗的临床对照研究 被引量:2

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摘要 目的探讨术前辅助性化疗对Ⅲ期非小细胞肺癌患者的临床疗效和预后生存的影响。方法将我院2003年1月至2006年1月收治的63例Ⅲ期非小细胞肺癌患者随机分为治疗组38例和对照组25例,比较两组之间临床疗效以及预后生存率。结果治疗组经术前MVP辅助性化疗,临床总有效率为44.7%。治疗组患者的手术切除率为86.8%,对照组患者手术切除率为56.0%,两组之间差异有统计学意义(P<0.01)。两组患者在手术时间以及术中出血量之间差异有统计学意义(P<0.05)。治疗组术后1年、3年和5年的生存率分别为84.2%、76.3%和47.4%,对照组术后1年、3年和5年的生存率分别为72.0%、44.0%和24.0%,两组之间预后生存具有统计学意义(P<0.01)。结论非小细胞肺癌术前辅助性化疗的近期疗效较好,能够有效提高手术切除率,提高患者的预后生存时间,对非小细胞肺癌的临床治疗具有重要的意义。
出处 《海南医学》 CAS 2011年第17期38-40,共3页 Hainan Medical Journal
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  • 1支修益,刘宝东,许庆生,张毅,苏雷,王辉荣,胡牧.CT和正电子发射计算机断层摄影显像对确定非小细胞肺癌纵隔淋巴结转移的临床价值[J].中华医学杂志,2005,85(29):2026-2029. 被引量:15
  • 2Novoa N,Varela G,Jimenez MF.Morbidity after surgery for non-small cell lung carcinoma is not related to neoadjuvant chemotherapy.Eur J Cardiothorac Surg,2001,20:700-704.
  • 3Jocelyne M,Robert JG,Amir A,et al.Morbidity and mortality after neoadjuvant therapy for lung cancer:the risks of right pneumonectomy.Ann Thorac Surg,2001,72:1149-1154.
  • 4Christophe D,Pascal T,Xavier T,et al.Postoperative complications in relation with induction therapy for lung cancer.Eur J Cardiothorac Surg,2001,20:385-390.
  • 5Luca V,Luca L,Claudia G,et al.Results of induction chemotherapy followed by surgical resection in patients with stage ⅢA(N2) non-small cell lung cancer:the importance of the nodal down-staging after chemotherapy.Eur J Cardiothorac Surg,2001,20:1106-1112.
  • 6Eberhardt W, Wilke H, Stamatis G, et al. Preoperative chemotherapy followed byconcurrent chemoradiation therapy based on hyperfractionated accelerated radiotherapy anddefinitive surgery in locally advanced non-small cell lung cancer: mature results of aphase Ⅱ trial. J Clin Oncol,1998,16(3)∶622-634.
  • 7Fleck J, Camargo J, Godoy D, et al. Chemoradiation therapy alone versuschemotherapy alone as a neoadjuvant treatment for stage Ⅲ non-small cell lung cancer.Proc Am Soc Clin Oncol,1993,12(2)∶333.
  • 8Gandara DR, Leigh B, Vallieres E, et al. Preoperative chemotherapy in stage Ⅲnon-small cell lung cancer: Long-term outcome. Lung Cancer,1999,26(1)∶3-6.
  • 9Rosell R, Gomez CJ, Camps C, et al. Preresectional chemotherapy in stage Ⅲnon-small cell lung cancer: a 7-year assessment of a randomized controlled trial. LungCancer,1999,47(1)∶7-14.
  • 10Roth JA, Atkinson EN, Fossella F, et al. Long-term follow-up of patients enrolleda randomized trial comparing perioperative chemotherapy and surgery with surgery alone inresectable stage ⅢA non-small cell lung cancer. Lung Cancer,1998,21(1)∶1-6.

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