摘要
1例26岁男性患者,因一氧化碳中毒后导致双下肢挤压伤入院。入院后行挤压综合征减张术后发生感染,肌肉持续坏死、筋膜感染,曾使用多种抗菌药物,感染控制不佳,多次分泌物培养为志贺氏菌属。临床药师会诊后,制订了个体化给药方案,第一疗程10 d:亚胺培南西司他丁联合克林霉素;第二疗程14 d:克林霉素联合哌拉西林他唑巴坦;第三疗程5 d:头孢呋辛。3 d后,体温正常,白细胞和粒细胞降低,21 d后无肌肉持续坏死现象,23 d后,体温、血常规均正常,感染得到控制。
One 26-year-old male patient with crush injuries to both lower extremities after being involved in carbon monoxide poisoning was admitted to hospital. After the operation for treatment of crush syndrome, he developed postoperative infection, sustained muscle necrosis and fascial infections. The patient used some antimicrobial agents, while the efficacy of infection control was poor, and Shigella was found from secretions. After consultation with clinical pharmacists, the individualized dosing regimen was made. In the first treatment course （10 days）, imipenem-cilastatin and clindamycin were combined. During the second course（14 days ）, clindamycin and piperacillin-tazobactam were given in combination. In the third course, cefuroxime was given for 5 days. Three days later, the body temperature was normal, the number of white blood cells and granulocytes decreased, 21 days later no continuing muscle necrosis occurred, 23 days later the body temperature and blood routine were normal, infection was controlled.
出处
《中国药物应用与监测》
CAS
2011年第4期221-223,共3页
Chinese Journal of Drug Application and Monitoring
关键词
挤压综合征
志贺氏菌
药学监护
感染
Crush syndrome
Shigella
Pharmaceutical care
Infection
