摘要
微RNA(microRNA,miRNA)是新发现的一类进化上高度保守的重要的转录后调控因子,通过调节基因的表达而参与调控细胞凋亡、增殖及分化等生理过程,同时与肿瘤等疾病的发生发展密切相关。近年来研究发现,miRNA、miRNA生物合成通路基因及miRNA的靶基因结合位点的遗传变异(例如单核苷酸多态性和拷贝数变异等)可影响miRNA调控功能的发挥,并产生显著的遗传学效应。文章主要综述了miRNA相关的遗传变异与肿瘤易感性和临床转归等的研究进展。
microRNAs（miRNAs） are a highly conserved class of small noncoding RNAs that regulate gene expression by post-transcriptional degradation or translational repression.miRNAs are involved in the regulation of cell apoptosis,prolif-eration,differentiation and other physiological processes,and are closely related with the development of cancer.More recently,it has been proposed that the presence of genetic variations（e.g.,single nucleotide polymorphism and copy num-ber variation） in microRNA genes,their biogenesis pathway and target binding sites affect the miRNA processing machin-ery and targeting,and have a significant genetic effect.In this review,we focus on the miRNA-related genetic variations and cancer susceptibility and progression.
出处
《遗传》
CAS
CSCD
北大核心
2011年第8期870-878,共9页
Hereditas（Beijing)
基金
国家科技重大专项(编号:2008ZX10002-016)
国家自然科学基金项目(编号:30900819
30901707)资助
