摘要
目的:检测原发性肝细胞癌(HCC)组织中环氧化酶-2(COX-2)及E-钙黏蛋白(E-cadherin)的表达。方法:采用免疫组化法检测64例HCC组织及12例正常肝组织中COX-2及E-cadherin的表达,并分析二者在HCC组织中的关联性及与临床病理特征的关系。结果:HCC组织中COX-2的表达高于正常肝组织(75.0%vs8.3%,χ2=16.805,P<0.001)。HCC组织中E-cadherin的表达低于正常肝组织(51.6%vs83.3%,χ2=4.152,P=0.042)。HCC组织中COX-2的表达与临床分期有关(χ2=9.069,P=0.011),E-cadherin的表达与组织分化程度(χ2=7.635,P=0.022)及临床分期(χ2=6.786,P=0.034)均有关。HCC组织中COX-2及E-cadherin蛋白的表达呈负关联(rP=0.324,P=0.006)。结论:HCC组织中COX-2蛋白高表达及E-cadherin蛋白低表达可能在HCC的发生、发展中发挥一定作用,二者联合检测可能用于预测HCC的侵袭性。
Aim：To investigate the expressions of cyclooxygenase-2（COX-2）and E-cadherin in hepatocellular carcinoma（HCC）tissue.Methods：The expressions of COX-2 and E-cadherin in 64 cases of HCC and 12 cases of normal liver tissue were detected by immunohistochemistry.Results：The expression rate of COX-2 in HCC tissue was higher than that in normal liver tissue（75.0% vs 28.3%,χ2=16.805,P0.001）.The expression rate of E-cadherin in HCC tissue was lower than that in normal liver tissue（51.6% vs 83.3%,χ2=4.152,P=0.042）.The expression of COX-2 in HCC tissue was related with clinical stage（χ2=9.069,P=0.011）.The expression of E-cadherin in HCC tissue was related with tissue differentiation（χ2=7.635,P=0.022）as well as clinical stage（χ2=6.786,P=0.034）.The expression of COX-2 and E-cadherin was negatively associated in HCC tissue（rP=0.324,P=0.006）.Conclusion：The high expression of COX-2 and low expression of E-cadherin in HCC tissue may play roles in the occurrence and development of HCC tissue,and the two markers are probably to become indicators predicting the invasive characteristic of HCC.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2011年第4期581-583,共3页
Journal of Zhengzhou University(Medical Sciences)
