摘要
为了研究和开发新的抗偏头痛药物，用电刺激三叉神经节和辣椒素静脉注射刺激的方法造成大鼠硬脑膜内血浆蛋白渗出，建立神经原性炎症动物模型。本实验观察到电刺激三叉神经节增加了刺激侧硬脑膜内１２５ＩＨＳＡ 的渗出，而非刺激侧１２５ＩＨＳＡ 的渗出水平未发生明显波动。在刺激后６０ ｍｉｎ 内，渗出量变化不大。另外观察到抗偏头痛发作药物二氢麦角胺（ＤＨＥ） 具有减少上述血浆蛋白渗出的作用。
Aanimal modelofneurogenicinflam mation was established through electricaltrigeminalganglion stimulation and capsaicin stimulationforstudying new anti migraine drug-Thosestimulationscause plasmaproteinleakage within rat dura mater-Electrical trigeminal ganglion stimulation markedly increases extravasation of 125I albumin from blood vessels withinipsilateraldura mater,butnot within unstimulatedside-Thevolumesofplasma protein ex travasation had not markedly changedin 60 min-In adition ,dihydroergotamine(DHE) ,an antimigraine drug,can decrease plasma extravasation-
关键词
血浆蛋白渗出
硬脑膜
偏头痛
神经原性炎症
plasma protein extravasation
dura mater
migraine
neurogenicinflam mation
