摘要
电刺激三叉神经节或静脉注射辣椒素造成大鼠硬脑膜内血浆蛋白渗出，取下双侧硬脑膜称重并测量其放射性。分别于刺激前４０ｍｉｎ腹腔注射ＨＬ－３２９１０、２０、４０ｍｇ／ｋｇ或相同容量溶剂，观察它们的作用。结果显示电刺激增加了刺激侧硬脑膜内血浆蛋白渗出〔（２１．５０±１．４５）～（３７．８５±３．１９）ｃｐｍ／ｍｇ，Ｐ＜０．０１〕，刺激侧与非刺激侧的比值为１．７６±０．１０。ＨＬ－３２９１０，２０，４０ｍｇ／ｋｇ分别减少其比值到１．５３±０．１４（Ｐ＜０．０５），１．４３±０．０３（Ｐ＜０．０１），１．２０±０．１５（Ｐ＜０．０１）。ＨＬ－３２９明显减少了电刺激和辣椒素造成的大鼠硬脑膜内血浆蛋白渗出。
Electrical unilateral trigeminal ganglion stimulation was performed on male Wistar rats (230280 g).HL329 10, 20, 40 mg/kg or tis vehicle were administered (ip) 40 min before stimulation.Both sides of dura mater were dissected and plasma protein leakage were examed by radioactivity measurement (c.p.m/mg wt).The results showed that Electrical trigeminal stimulation increased the leakage of 125Ialbumin within rat dura mater ratio=176±010 (from 2150±145 to 3785±319 cpm/mg, P<001).HL329 (at the dose of 10, 20, 40 mg/kg) decreased the ratio from 176±010 to 153±014 (P<005), 143±003 (P<001), 120±015 (P<001) respectively.HL329 significantly reduced plasma protein extravasation following electrical stimulation in the trigeminal ganglion in the rat ipsilateral dura mater.This might be of clinical importance for the treatmena of acute vascular headaches.
