摘要
本文采用离子交联的方法,研究制备了聚乙二醇(PEG)修饰的水溶性壳聚糖(WSC)药物载体。以牛血清蛋白(BSA)作为模型蛋白药物,对纳米粒子的物理化学性质作了初步检测。由于分子间的竞争作用,PEG的修饰在一定程度上降低了WSC纳米粒子的药物负载能力。体外释放实验表明PEG修饰的纳米粒子在一定程度上加快了BSA的释放,但仍具有较好的缓释性能。
PEG modified WSC nanoparticles were prepared based on ionic gelation and the capability of PEG modified water-soluble chitosan（WSC） was used as carriers to load and delivery drug.As a model protein drug,bovine serum albumin（BSA） was incorporated into the nanoparticles.Physicochemical of characterizations of WSC nanoparticles was determined preliminarily.PEG introduction might decrease loading capability of nanoparticles due to the competition effect between BSA and PEG.And in vitro release demonstrated that PEG modification could increase release of loading protein drug but the nanoparticles displayed a good release performance still.
出处
《现代食品科技》
EI
CAS
2011年第8期885-886,911,共3页
Modern Food Science and Technology
