摘要
目的:探讨癫痫患者口服丙戊酸钠(VPA)稳态谷浓度与体内病理生理因素以及联合用药的相关性,为临床合理使用VPA提供参考依据。方法:采用回顾性调查方法在空军总医院收集30例因癫痫口服VPA的患者病历资料,记录患者性别、年龄、VPA单位体重剂量、血药浓度及相应生化检验值。应用SAS软件(6.04版)对数据进行多元线性回归分析。结果:VPA稳态谷浓度与血清白蛋白(ALB)、单位体重剂量(mg.kg-1)具有显著正相关性(P<0.05);与肝药酶诱导剂具有显著负相关性(P<0.05)。结论:临床使用VPA时应重点考虑ALB、单位体重剂量和肝药酶诱导剂对VPA血药浓度的影响,定期监测其血药浓度。
OBJECTIVE： To investigate the correlation between sodium valproate（VPA） steady state concentration and the physiological and pathological factors and combined drug use in patients with epilepsy in order to provide reference for clinical rational use of VPA.METHODS： By a retrospective study,the medical records of 30 epileptic patients who received VPA orally were collected from General Hospital of Air Force of PLA and the clinical data such as gander,age,body weight,dosage of VPA,blood concentration and the corresponding biochemical testing values were recorded and the data were given multiple linear regression analysis by using SAS software（6.04 version）.RESULTS： VPS steady state trough concentration was in a significantly positive correlation with serum albumin and dose of unit weight（mg·kg-1）（P0.05） but in a significantly negative correlation with inducers of drug-metabolizing enzymes（P 0.05）.CONCLUSION： Great importance should be attached to the effects of albumin,dose of unit weight and the inducers of drug-metabolizing enzymes on the blood concentration of VPA in clinical use and it is necessary to perform regular monitoring of blood concentration of VPA.
出处
《中国医院用药评价与分析》
2011年第7期629-631,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
丙戊酸钠
血药浓度监测
多元线性回归
Sodium valproate
Blood concentration monitoring
Multiple linear regression
