摘要
制备家兔切割伤模型，分别以壳聚糖敷料和纱布包扎创面，血止后以氰化高铁血红蛋白试剂及光度比色法检测敷料中血红蛋白的含量。借此估计出血量。重新包扎创面，并于分阶段取材后应用常规病理学手段结合图像分析法观察病变。结果表明：壳聚糖包扎组出血量明显少于纱布对照组。伤后９天，壳聚糖治疗组创面肉芽组织层较厚于油纱布对照组，其中胶原纤维含量亦较多，伤口愈合较快。
Incised wounds were made in rabbits, and some of the wounds were dressed with chitosan, and others with gauze. After bleeding stopped, hemoglobin in dressings was measured to determine the hemostaic effect. Wounds were redressed, and healing process was studied histologically. The results showed that less Hb was detected in chitosandressing than in gauze. On day 9 after wounding, the content of granulation tissue and collagen formation in the chitosan dressed wounds was more than that in Vaseline gauze dressed group. It suggests that chitosan dressing is effective in hemostasis for incised wounds and may be helpful in wound healing process.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1999年第6期429-431,共3页
Medical Journal of Chinese People's Liberation Army
基金
"九.五"军队医药卫生科研基金!重点课题(96Z008
