摘要
以5-羟基-2-戊酮为原料经过酯化、氯化及关环反应,得到中间体2-氨基-4-甲基-5-(2-乙酰氧基)噻唑,在浓H2SO4作用下,用NaNO2和NaH2PO2还原氨基,最后通过皂化反应得到目标产物4-甲基-5-(2-羟乙基)噻唑,采用IR,1H NMR和13C NMR对产物的结构进行了表征确认。
2-amino-4-methyl-5-thiazolylethyl acetate, an reaction intermediate was synthesized from 3-acetyl- propanol via esterification,chloronation and cyclization. Then this chemical was reduced by sodium nitrite and sodium hypophosphite in the presence of concentrated sulfuric acid. Afterward,The target product 4- methyl-5-thiazoleethanol was eventually obtained through saponification. The structures of all compounds were confirmed by IR,1H NMR and 13C NMR.
出处
《南昌大学学报（理科版）》
CAS
北大核心
2011年第3期256-257,262,共3页
Journal of Nanchang University(Natural Science)
