摘要
以4-羟基苯甲醛为原料,经氰化、硫化、成环、Duff反应4步得到中间体2-(3-甲酰基-4-羟基苯基)-4-甲基-5-噻唑甲酸乙酯,后经醚化、氰化、水解得到Febuxostat,产物经IR1、H NMR1、3C NMR、MS和元素分析证实。
Febuxostat was synthesized from 4-hydroxybenzaldehyde in this study Four-step reactions inclu ding cyanidation, thioformylation, cyclization, Duff reaction were performed generate ethyl 2-（3-formyl-4 hydroxyphenyl）-4-methyl-5-thiazolecarboxylate, which was then processed by etherification, cyanidatio and hydrolysis to form the final product, febuxostat. The structure of the target compounds were confirme by IR,1H NMR,13C NMR,MS and elemental analysis.
出处
《南昌大学学报（理科版）》
CAS
北大核心
2011年第3期238-240,共3页
Journal of Nanchang University(Natural Science)
基金
江西省自然科学基金资助项目(2008GZH0043)
南昌大学科技基金资助项目(2009)
