Nogo-A expression in injured spinal cord following human olfactory mucosa-derived olfactory ensheathing cells transplantation 被引量：1

Nogo-A expression in injured spinal cord following human olfactory mucosa-derived olfactory ensheathing cells transplantation

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摘要 Transplantation of olfactory bulb-derived olfactory ensheathing cells （OECs） promotes motor functional recovery in rats with acute spinal cord injury, possibly by Nogo-A expression changes at the injury site. The present study transplanted OECs derived from the olfactory mucosa （OM） of rats OM-derived OEC （OM-OEC） transplantation significantly reduced the increase of Nogo-A protein and mRNA expression caused by spinal cord injury, supporting the hypothesis that OM-OECs improve spinal cord regeneration by reducing Nogo-A expression. Transplantation of olfactory bulb-derived olfactory ensheathing cells （OECs） promotes motor functional recovery in rats with acute spinal cord injury, possibly by Nogo-A expression changes at the injury site. The present study transplanted OECs derived from the olfactory mucosa （OM） of rats OM-derived OEC （OM-OEC） transplantation significantly reduced the increase of Nogo-A protein and mRNA expression caused by spinal cord injury, supporting the hypothesis that OM-OECs improve spinal cord regeneration by reducing Nogo-A expression.

作者 Bin Wang Qiang Li Xijing He Weixiong Wang

机构地区 Department of Emergency Surgery Department of Orthopedics [

出处《Neural Regeneration Research》 SCIE CAS CSCD 2011年第16期1217-1221,共5页 中国神经再生研究（英文版）

基金 the Doctoral Priming Foundation of Guangzhou Medical University

关键词 Spinal cord injury olfactory ensheathing cells olfactory mucosa cell transplantation neural regeneration Spinal cord injury olfactory ensheathing cells olfactory mucosa cell transplantation neural regeneration

分类号 Q426 [生物学—神经生物学] S857.18 [农业科学—临床兽医学]

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